What to do if your friend doesn't like the one your with??

When it comes to the opinions of your friends and your loved ones about your personal life, their's usually matters the most. But what do you do when the people that matter the most to you, dislike the person your in love with? It's kind of difficult to maintain a relationship when the two most important people in your life don't get along. You don't want to choose sides; its almost as if you're literally caught between a rock and a hard place. On one hand you can sides, boys may come and go, but good friends are forever. Also, what if the one you're with now is one of the best things that happened to you? Are you suppose to give up the one your with just please somebody? All these questions play over and over in your mind, for me especially since i'm in a similar situation right now. I don't even have an answer for myself. It's hard not to step on anyone's toes, but at the end of the day, you have to do whats best for you. As in outsider looking in... is the best thing to do in this situation?